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Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells

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Figure

Fig. 1 Itraconazole inhibits the growth of gastric cancer cells in vitro and in vivo.d(vehicle (or a combination of itraconazole and 5-FU (ITRA + 5-FU;itraconazole, 10a Decrease in viability of gastric cancer cells (AGS and MKN45)following treatment with i
Fig. 2 Effects of itraconazole on cell cycle distribution and apoptosis of gastric cancer cells.cytometry analysis in AGS and MKN45 cells after treatment with different concentrations of itraconazole or DMSO for 72 h
Fig. 3 Itraconazole inhibits the expression of Gli1 in gastric cancer cells.of major molecules of Hh signaling are determined by immunoblot
Fig. 4 Immunostaining analysis of the Hh signaling molecules (SHH and GLI1) in human gastric cancer tissues
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