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Neoadjuvant ipilimumab (3 mg/kg or 10 mg/kg) and high dose IFN-α2b in locally/regionally advanced melanoma: safety, efficacy and impact on T-cell repertoire

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Figure

Table 2 Adverse events (worst grade; ≥ 2pts) possibly, probablyor definitely related to the study regimen (N = 30)
Table 3 Grade 3–4 immune related adverse events divided by study arm (N = 30 patients)
Fig. 1 Peripheral blood mononuclear cells (PBMC) T-Cell Clonality inpatients with no evidence of disease relapse after surgery (durableNED) versus patients with disease progression with or withoutsubsequent death (PD/CTB)
Fig. 3 Tumor infiltrating lymphocyte (TIL) clonality in primary melanoma tumor biopsies (Primary Tumor) and post-treatment metastatic melanomabiopsies (Post Tx Met; approximately 6–8 weeks from baseline)

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