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Selective antitumor activity of roscovitine in head and neck cancer

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Figure

Figure 1: Roscovitine induces p53- and ATM-independent phosphorylation of H2AX and selectively inhibits growth in HPV-positive head and neck cancer cells
Figure 2: Roscovitine treatment activates p53 and induces p53-dependent suppression of HPV-positive cells growth
Figure 3: Roscovitine does not induce DNA double strand breaks as indicated by the absence of 53BP1 foci formation
Figure 4: Roscovitine induces RPA foci formation in HPV+, but not in HPV-, head and neck cancer cells
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