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Claudin 18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis

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Figure

Figure 1. Increased cellularity, alveolar epithelial type II (AT2) cell abundance, and parenchymal expansion in Cldn18*cells (green) in Unpaired 2-tailed thickness in mice are increased
Figure 2. Increased alveolar epithelial type II (AT2) cell proliferation in Cldn18iodide
Figure 3. Activation of YAP signaling in whole lung and alveolar epithelial type II (AT2) cells in Cldn18nimage shows increased nuclear YAP (increased YAP and decreased p-YAP in DAPI (blue) is the nuclear counterstain
Figure 4. YAP inhibition decreases proliferation and colony-forming efficiency (CFE) of alveolar epithelial type II (AT2) cells from Cldn18pendent experiments
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