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mTORC1 loss impairs epidermal adhesion via TGF β/Rho kinase activation

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Figure

Figure 1. Epidermal-specific mTORC1 loss-of-function models have skin barrier defects
Figure 2. mTORC1 loss of function does not significantly alter epidermal proliferation or apoptosis, but is associated with abnormal mitotic polariza-tion
Figure 3. mTORC1 loss of function in the epidermis results in cell-cell adhesion defects
Figure 4. mTORC1 loss of function is associated with reduced desmosomal mRNA expression and is compensated by transfection of exogenous des-mosomal cadherins
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