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A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin

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Figure

Figure 1 Distribution of subjects assigned to age- and weight-based cohorts. BMI 15–18.9 kg/mBMI >40 kg/mNotes: A total of n=88 subjects were assigned to either the age- or weight-based cohort
Table 1 Demographic characteristics of study subjects
Table 2 PK parameters of HPβCD-diclofenac in the age-based cohort (n=28 subjects; excludes subjects with aberrant plasma diclofenac measurements)
Table 3 PK parameters of HPβCD-diclofenac in the weight-based cohort (n=53 subjects; excludes subjects with aberrant plasma diclofenac measurements)
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