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Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner

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Academic year: 2020

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Figure

Figure 1 Transmission electron microscopy (TeM) picture of RgD-UsPIO nanoparticles. TeM examination indicated that the size of RgD-UsPIO particles was 10 ± 2 nm.Abbreviations: RgD-UsPIO, arginine-glycine-aspartic acid peptide conjugated ultra-small superparamagnetic iron oxide nanoparticles (RgD-UsPIO).
Figure 3 Transmission electron microscopy images of hUVecs co-cultured with RgD-UsPIO for 10 min A) and 30 min B) or UsPIO for 30 min C) at the iron concentration of 0.03 µmol/mL
Figure 4 he and sP staining of tumor cells  (A, B) or tumor tissues (C–F).  The different expression patterns of αvβ3 integrin were shown by sP staining
Figure 5 Pseudo-color magnetic resonance (MR) images of tumors after the of UsPIO injection of RgD-UsPIO A) and T2-weighted MR images of tumor after the injection B) Pseudo color MR images reflected the reduction of signal intensity in 3LL tumor mainly dis
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