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Synergistic and complete reversal of the multidrug resistance of mitoxantrone hydrochloride by three-in-one multifunctional lipid-sodium glycocholate nanocarriers based on simultaneous BCRP and Bcl-2 inhibition

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Academic year: 2020

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Figure 1 The proposed schematic illustration of three-in-one multifunctional lipid-gcNa nanocarriers (TMlgNs).Abbreviations: gcNa, sodium glycocholate; BcrP, breast cancer resistance protein; Peg-Pe, 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethyleneglycol)-2000].
Table 1 summary of particle size, zeta potential, and drug encapsulation efficiency of MTO-NLCs and MTO-TMLGNs (mean ± sD, n=3)
Figure 3 Distribution of MTO in tissues of mice (Abbreviations:B – 0.5 hour; C – 4 hours) and mean plasma concentration–time curves of MTO in rats after the intravenous administration of MTO-sol and MTO-TMlgNs at a dose of 1 mg/kg (A) (mean ± sD, n=6)
Table 2 Main pharmacokinetic parameters of MTO in rats after the intravenous administration of MTO-sol and MTO-TMlgNs at dose 1 mg/kg (mean ± sD, n=6)
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