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The contribution of Roberto Montesano to the study of interactions between epithelial sheets and the surrounding extracellular matrix

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Figure

Fig. 1. A portrait of Dr. Roberto Montesano (courtesy of Dr. Montesano).
Fig. 2. A scheme of the three dimensional cell culture system showingthat VEGF induces microvascular endothelial cells grown on collagen gelsto invade the underlying matrix (courtesy of Dr
Fig. 3. Principal factors studied by Roberto Montesano and collabo-rators.endothelial growth factor; TGF-nogen activator; bFGF, basic fibroblast growth factor; VEGF, vascularAbbreviations: PMA, phorbol myristate acetate; uPA, urokinase plasmi-epithelial cells by using an original three-dimensional cell culture system.tubulogenesis of Madin-Darby canine kidney (MDCK) cells and mammary Schematic drawing of molecules involved in angiogenesis andβ1, transforming growth factor beta 1;HGF, hepatocyte growth factor; RA, retinoic acid.

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