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Friday, December 7, 2012

Instructional presentations

Basics of biomechanics and cross-linking Chair: G. Kymionis

09:00 Basics of cross-linking
 Spoerl, Eberhard (Germany) invited

09:15 Fluence, illumination time and beam profile Mrochen, Michael (Switzerland) 09:30 Biomechanics of the cornea Kling, Sabine (Spain) invited

09:45 Discussion

10:00–10:30 Coffee break

Using diagnostic devices Chair: J. Frucht-Pery

10:30 Corneal Topography and the ERSS score, an update Randleman, Brad (USA) 10:45 Scheimpflug topography Ambrosio, Renato (Brazil) invited

11:00 Discussion

11:30-12:45 Lunch

Established & new indications, patient selection Chair: D. Epstein, G. Kymionis

12:45 Keratoconus, PMD and iatrogenic keratectasia Gaster, Ronald (USA) invited

13:00 CXL with / following refractive laser surgery Kymionis, George (Greece) invited

13:15 Indications for CXL in adults and children Frucht-Pery, Joseph (Israel) invited

13:30 Transepithelial CXL – fiction and reality Raiskup, Frederik (Germany) invited

13:45 Predicting factors of visual acuity improvement after CXL Vinciguerra, Paolo (Italy) invited

14:00 Discussion

Company Courses (Open for all participants)

14:15–15:00 SOOFT Italy: Iontophoresis: the definitive CXL Chair: P. Vinciguerra

What we know today about ocular iontophoresis Joseph Frucht-Pery Transepithelial CXL: current technique and future directions David 0' Brart Evaluation of riboflavin distribution induced by corneal Franccis Malecaze iontophoresis and effects on collagen fibers after Myriam Cassagne iontophoresis + UV-A irradiation

Structural modifications and tissue response after current Leonardo Mastropasqua transepithelial CXL vs iontophoretic transepithelial CXL Mario Nubile

Histological analysis after CXL via iontophoresis: overall Rita Mencucci evaluation on epithelium, stroma and endothelium

Comparative stress-strain measurements of human corneas Paolo Vinciguerra after transepithelial UV-A induced CXL: impregnation with

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15:00 – 15:45 Avedro: New Science, New Applications Chair: David Muller Accelerated Cross-Linking Safety John Marshall, PhD New Cross-linking Science Marc Friedman, PhD Trans-epithelial cross-linking with ParaCel Peter Hersh, MD Lasik Xtra and AK Xtra John Kanellopoulos, MD The Future David Muller, PhD

15:45 – 16:15 Coffee break

16:15 – 17:00 Peschke Meditrade

Crosslinking for infectious Keratitis THEN - Now – FUTURE Jes Mortensen 17:00 – 17:45 IROC Innocross: Update from the innovator of CXL Chair. M. Mrochen

The IROC INNOCROSS Product Range John Mc Master

The treatment protocol with the UV-X 2000 Victor Derhartunian, MD 6 month clinical data with the UV-X 2000 Arthur Cummings, MD A brief update on the ORA David Taylor

17:45 – 18:30 Short communications Chair: B. Randleman Basic

17:45-17:50 Effect of Higher Intensity Corneal Cross-Linking (CXL) In-Vitro using Second Harmonic (SH) Optical Microscopy. (A-41)

McQuaid, Rebecca (Ireland) 17:50-17:55 Keratoconus corneal Architecture after cross-linking by

riboflavin/UVA - Ultrastructural studies. (A-33)

Akhtar, Saeed (Saudi Arabia) 18:00-18:05 The Effect of Riboflavin/UVA Collagen Cross-linking on Stromal

Ultrastructure and Fluid Dynamics. (A-12)

Hayes, Sally (Great Britain)

Clinical

18:05-18:10 Consensus on reporting parameters for scleral and corneal biomechanical measurements. (A-51)

Richoz, Olivier (Switzerland) 18:10-18:15 Evaluation of Keratoconus Match Index and Keratoconus Match

Probability in the Diagnosis of Forme Fruste Keratoconus. (A-40)

Gatzioufas, Zisis (Germany) 18:15-18:20 Results of the personalized krosslinking treatment of

keratoektazies. (A-25)

Anisimov, Sergei I. (Russia) 18:20-18:25 Intra and Inter-observer variability of measurements with

Pentacam HR® in patients with mild to moderate keratoconus. (A-68)

Majo, François (Switzerland) 18:25-18:30 A new protocol for treatment of severe infectious keratitis:

Corneal Collagen Cross-Linking Window Absorption (CXL –WA). (A-17)

Rosetta, Pietro (Italy) 18:30-18:35 Characteristics Influencing Outcomes of Corneal Collagen

Crosslinking for Keratoconus and Corneal Ectasia: Development of a Patient Treatment Algorithm. (A-2)

Hersh, Peter (United States) 18:35-18:40 Refractive Cross Linking. The next generation of keratorefractive

procedure (A-46)

El Hage, Sami (United States)

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Posters

Posters will be displayed in the main meeting room during the conference Poster 1 (A-7)

UV collagen Cross-Linking in paediatric age Fortunato, Michele (Italy)

Poster 2 (A-79)

Assessment of accelerated Collagen Cross-Linking for the treatment of refractory bacterial keratitis in dogs and cats (8 cases)

Frank Famose (Switzerland)

Poster 3 (A-13)

Transepithelial CXL and standard CXL: a comparative morfological study throught confocal microscopy and OCT anterior segment

Gabbriellini, Giovanna (Italy)

Poster 4 (A-14)

Keratotensotopography - new diagnostic possibilities for studying the biomechanical properties of the cornea duiring CXL

Anisimov, Sergey (Russia)

Poster 5 (A-16)

Corneal cross-linking as a treatment for keratoconus: Four-year morphological and clinical outcomes with respect to patient age.

Vinciguerra, Riccardo (Italy)

Poster 7 (A-24)

The study of the morphological changes in the cornea after krosslinking conducted in experiment Zolotorevskiy, Kirill A. (Russia)

Poster 8 (A-26)

Pockmarked transepithelial crosslinking for keratoconus: one-year results Rechichi, Miguel (Italy)

Poster 9 (A-27)

Results of progressive hyperopic shift correction by сombined local corneal crosslinking in patients after radial keratotomy

Kalinnikov, Yurii (Russia)

Poster 10 (A-29)

Transepithelial PTK for “Epithelium OFF” topo-guided CXL. Kovalov, Andriy (Ukraine)

Poster 11 (A-35)

Histological changes in eye-banked human corneas after standard and high intensity cross-linking with riboflavin and UV-A

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Poster 12 (A-36)

Zernicke Values as a Measure of Collagen Crosslinking Effectiveness Saponara, Fiorella (United States)

Poster 13 (A-44)

Collagen Crosslinking in progressive Keratoconus – 5 years follow-up Constantin Mihaela Monica & Corbu Catalina (Romania)

Poster 15 (A-47)

Comparison of Laser-Assisted Removal of Epithelium to Mechanical Debridement in Corneal Cross-Linking for Progressive Keratoconus: 6-Month Results

Gaster, Ronald (United States)

Poster 17 (A-53)

Effect of collagen cross-linking on the limbal stem cells. Richoz, Olivier (Switzerland)

Poster 18 (A-58)

Modification of collagen cross-linking parameters for the treatment of acanthamoeba keratitis Richoz, Olivier (Switzerland)

Poster 19 (A-61)

LASEK+CXL in Keratoconic patients Borissova, Jenny (Bulgaria)

Poster 20 (A-65)

Combined Alcohol-Assisted Topography-guided Phototherapeutic Keratectomy and Accelerated Corneal Collagen Cross-Linking for Pellucid Marginal Degeneration

Aoyama, Masaru (Japan)

Poster 21 (A-66)

Corneal morphological changes of corneal collagen crosslinking in Canada Al-Ghoul, Ahmed (Canada)

Poster 22 (A-72)

Treatment of cornea hydrops with UV cross linking Geerards, Annette (Netherlands)

Poster 23 (A-74)

Biomechanical analysis on the effect of permanent myopia reduction by following trans-epithelial Crosslinking with Ortho-K

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Saturday, December 8, 2012

Scientific program

08:10-08:15 Introductory remarks and welcome Hafezi, Farhad (Switzerland)

Basic research

Chair: E. Spoerl, K. Meek

08:15-08:30 Corneal shape supported by collagen organization Meek, Keith (UK) invited

08:30-08:45 Corneal biomechanics, age-related changes Elsheikh , Ahmed (UK) invited

08:45-09:00 Corneal biomechanics, hormonal influences Gatzioufas, Zisis (Switzerland)

invited

09:00-09:15 Biomechanical changes in standard and rapid CXL Schumacher, Silvia (Switzerland)

invited

09:15-09:30 Spatially depth-resolved corneal elasticity: applications to CXL Kling, Sabine (Spain) invited

09.30-09:45 Corneal Biomechanical Properties at Different CXL-Fluences (A-43)

Richoz, Oliver (Switzerland) 09:45-10:00 Determination of the excimer laser ablation rate in previously

cross-linked cornea. (A-49)

Alba Mosquera, S. (Germany) 10:00-10:15 Discussion

10:15-10:30 Light for Sight Hafezi, Nikki & Hafezi, Farhad (Switzerland)

10:30-11:00 Coffee break

Translational research

Chair: F. Majo, M. Mrochen

11:00-11:10 Rapid CXL and LASIK Seiler, Theo (Switzerland) invited

11:10-11:20 Comparative Stress Strain and Histological Measurements Of Human Corneas After UV-A Induced Cross-linking:

Impregnation With Iontophoresis, Different Riboflavin Solutions And Irradiance Power

Vinciguerra, Paolo (Italy) invited

11:20-11:25 ”Corneal Crosslinking and iontophoresis: Biomechanical and histological ex vivo study.” (A-60)

Mastropasqua, Leonardo (Italy) 11:25-11:30 Combining Iontophoreis and CXL: a basic study on human

corneas. (A-28)

Mencucci, Rita (Italy) 11:30-11:40 Long-term impact of CXL upon corneal permeability in a live

rabbit model. (A-55)

Stewart, Jay (USA) 11:40-11:50 Discussion

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Clinical research

Chair: P. Vinciguerra, B. Randleman

13:00-13:10 Irradiation profiles Koller, Tobias (Switzerland) Invited

13:10-13:17 Epithelial Remodeling after Corneal Collagen Cross-linking Evaluated by Spectral-domain OCT. (A-78)

Randleman, J. Bradley (USA) 13:17-13:24 UV-A absorption rate of fluorescein and its impact on the

efficacy of collagen cross-linking (CXL) for infectious corneal melting. (A-50)

Richoz, Olivier (Switzerland) 13:24-13:31 Corneal collagen crosslinking in advanced keratoconus with

ultra-thin corneas. (A-62)

Wajnsztajn, Denise (Israel) 13:31-13:38 Is corneal collagen crosslinking effective in the treatment of

advanced keratoconus? (A-63)

Cagil, Nurullah (Turkey) 13:38-13:45 Two Years Results of Topo-guided PRK after ICR segments

implantation and corneal collagen crosslinking in a three-step procedure for keratoconus. (A-76)

Coskunseven, Efekan (Turkey) 13:45-13:52 Safety and Efficacy of High-Fluence CXL for Progressive

Keratoconus; Short-Term Results (A-42)

Richoz, Olivier (Switzerland) 13:52-13:59 Reduction of femtosecond astigmatic keratotomy (fsAK)

regrassion with combined simultaneous high fluence CXL (hfCXL). A novel refractive procedure

Kanellopoulos, John (Greece) 13:59-13:06 Analysis of Keratoconus using Keratoconus Prediction Index

and Cone Location & Magnitue Index. (A-48)

Ramani, Veera (Malaysia) 14:06-14:30 Discussion

14:30-15:00 Coffee break

Recommendation

Chair: F. Hafezi, P. Rosetta

1) Recommendations on CXL in children

15:00-15:20 Decision making and outcome of CXL in children Frucht-Pery, Joseph (Israel)

2) Reporting results – are we comparing apples to oranges? Finding a consensus on reporting outcomes

15.20-15:25 Refraction? Seiler, Theo (Switzerland) invited

15:25-15:30 Epithelial map? Randleman, J. Bradley (USA) 15:30-15:35 Keratokonus indices? Ambrosio, Renato (Brazil) invited

15:35-15:40 Kmax? Reporting the error Mrochen, Michael (Switzerland) 15:40-16:00 Discussion

3) Corneal Limbus: to irradiate or not, an update

16:00-16:05 Pro Majo, François (Switzerland) invited

16:05-16:10 Contra Tba 16:10-16:20 Discussion

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4) PRK and CXL – in parallel or sequentially

16.20-16.30 Incidence of Emmetropia in Keratoconus cases Treated with same-session Corneal Collagen Cross-linking and Topography-guided PRK (A-54)

Al-Tuwairqi, Waleed (Saudi Arabia)

16:30-16.40 Limited topography guided surface ablation combined with corneal crosslinking for progressive keratokconus: a randomized trial. (A-34)

Schmidinger, Gerald (Austria) 16:40-16:55 Discussion

5) Transpepithelial

16:55-17:05 EPI-ON cross-linking: 3 years results and suggestions for the selection of the patient (A-10)

Gualdi, Luca (Italy)

17:05-17:15 Contra Hafezi, Farhard (Switzerland) 17:15-17:30 Discussion

17:30 The Theo Seiler Young Researcher Award

(Euro 500.00)

Hafezi, Farhard Mrochen, Michael Randleman, J. Bradley 17:45 Final remarks Hafezi, Farhad

References

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