1
Biobanks,
an
under
‐
used resource
Mark Divers
Karolinska Institutet Biobank och BBMRI.se
Vinnova‐VR workshop , Stockholm, juni 2012
Forskningsinfrastruktur för industriella innovationer
But biobanking is hot!
•
Big
interest
• >$1B technology spend per year
•
Big
population
studies
appeared
• Hunt, deCode, UK Biobank, LifeGene, LifeLines, Kadoorie
•
Big
analysis transformation
• Genetic and protein technologies
•
Big
discussion
• Many hopes, many fears
2
Growing impact on
medical research
What is
a
biobank?
•
Organiserad
collection of biological samples
– Often human
•
Archived long
‐
term
– Frozen: ‐20, ‐80, ‐190°C
•
Searchable &
accessible
– Samples and data
•
Used for
research,
development and
healthcare
– Described as gold‐mine!
•
Regulated by
law
Biobank landscape of Sweden
•
579 Biobanks
3
Biobank landscape of Sweden
– for healthcare
Tissue 114 M sampels Cells 28, 7 M Blood/plasma 4530000 Serum 2200000 DNA/RNA 69000 Bone 110000 Others 106000Biobank landscape of Sweden
– for research
Blood/Plasma 4,2 M Serum 2,3 M DNA/RNA 572000 Tissue 51000 Urin 230000 Salivia 112000 Other 47000The
biobanks
of KI
and
BBMRI.se
are a
rich source
of samples:
150
studies
Population cohorts
• TwinGene, LifeGene,
EpiHealth
• Karma, Stockhom‐2
Disease based studies
• Cancer • CV • Neurological • Inflammatory • Immunological Quality registers
A good climate for biobank-based
research in Sweden
•
Well
‐
characterised population
• personal number system • systematic registries
•
Track
‐
record
• Eg Swedish Twin Registry ”TwinGene”
•
Large population
cohorts emerged 2009
5
But challenges too
•
Fragmentation
•
Organisational
•
Logistic
•
Economic
•
Complex ethico
‐
legal
landscape
EU BBMRI initiative: our chance to
create biobanks of the future
•
Technology:
test
and
apply
the
best!
•
Network:
connect
modern
biobanks!
• Vision: 300 biobanks throughout EU
•
Harmonise:
evolve
common
standards!
•
Add
big
public
health
value!
Swedish
Science
Research
Council
and
KI
fund BBMRI.se
for
5
years
large-Scale Swedish Biobanking (SSB);
a service for big national studies
Some biobank
accounts May
2012
Total KIBB BBMRI.se
# studies 150 140 10
# samples 2 634 210 584 578 2 049 632 # donors 233 950 153 201 80 749 # DNA samples 197 519 138 963 58 556 # withdrawals >225 000 >175 000 >50 000
7
Creating a BBMRI.se national network
13
Progressive build up in medical universities
•Goteborg node •launch Jan 2012 •1st project: Scapis •Malmö node •launch 1Q2012 •1st projects: EpiHealth, MKC, MFM
•Linköping, Umeå, Uppsala to come
•Linköping launch 1H2013?
•Projects identified
Starting co‐ordination with healthcare biobanking Co‐ordinated:
• Sample format
• Data format
• Processes
• Equipment & consumables
• Access and use
Unifying Swedish
biobanks
further
University
+
Healthcare
biobanks
•
National
common
infrastructure
–
VR
‐
SKL
declaration
•
Regional
partnerships,
eg
–
Uppsala
biobank
–
Göteborg
–
Region
Skåne
–
KI
– SLL
Why are we biobanking?...
…
to
advance medical research!
•
Combine with modern
bio
‐
analysis
• Systematic • Statistical power
•
Huge
potential
for
public
health
Study publications GALLSTEN 4 PAIN 2 BAMSE 8 SCALE 15 Ekonomiskt beteende 2 TwinGene & Euroclot 13 HARMONY & SATSA 12
KTS 1 CAPS 40 Totalt 97 Emerging highlights •Multiple Sclerosis •TwinGene •Broad
•Influenza Like Illnesses
•Prostate Cancer
What is
the
value of biobanking?...
Multiple Sclerosis research gives a great example*
•
~17K
MS
cases in
Sweden
•
Many represented in
our biobank
•
New
therapy,
Tysabri™
• Monoclonal antibody
• Very effective, very expensive
• Serious side effects in some (polyoma viral cross‐reacton)
9
Biobanking adds big value
Clinical
practice
Health
economy
Drug development
Ethical credibility
Better screening, diagnosis and
treatment match
Better public health for lower cost
Increased trust and support
Matching patients to treatments
eg HPV, MS
eg MS, HIV, HPV
eg HPV
2012-01-03 Mark Divers
Biobanks
for
industrial innovation?
Discovery
&
Development
•
Pharmaceuticals
–
Biomarkers
–
Patient
subtyping
–
Metabolites
–
Safety profiling
•
Diagnostics
•
…
19 Lab Operations Carita Rask Jaspal Singh Cecilia Agardh Peter Arnerlöv Anci Carman Pia Hillelson Camilla Lagerberg Vian Osman Amina Said Anette Selander Johanna Smith Siwonne Andersson Emma Ridell William Day Valentina Novak Karin Lindqvist Biobank IT Eva Büren Staffan Bergh Jonas Birgersson Ulrika Bohlin Jesper Lind Johan Stenninger José Tapia Anni Åsberg Niclas Ahlin Project coordination Anders Brinne Biobank Development Gunnel Tybring Quality Anette Petersson Mirja Larsson
Acknowledgements
The LifeGene Crew including Jens Mattsson Kicki Kjaergaard Mats Thurman Camilla Björk Thomas Bergman
The BBMRI Crew
Joakim Dillner Jan-Eric Litton Mats Hansson Göran Hallmans Ulf Landegren Joakim Galli Lars-Olof Hansson Joyce Carlsson Lisen Arnheim-Dahlström Sofie Pettersson Martin Fransson Loreana Norlin Maria Anderberg Others @ KI Henrik Grönberg Per Hall Nancy Pedersen Rune Franson Per Spångeus Customer Relations Tove Rylander-Rudqvist Cecilia Björkdahl
The Biobank Crew
More info
http://ki.se/kibiobank www.bbmri.se www.lifegene.se
