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Control of cell differentiation and morphogenesis in amphibian development

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Figure

Fig. 1. Methodsfor bioassayof inducingfactors.fa) Implantationmethod or Emsteck method
Fig. 2. Diagramof chemicalprotein,structureof activinsand inhibinswhichbelongto TGFBsuperfamilyproteins.In TGF6superfamilywe canobservethe we"conservedcysteineresiduesin theiraminoacidse-quences.MIS
Fig. 3. DiagrammaticAsashlmaAriizumiactivinrenal tubulesment) are induced (Asashima et al., 1990:ing heartrepresentationof the animal cap assay and explantsafter activin treatment.Dependingonthe activin concentration,many meso-dermal tissuesfrom ventral type meso-derm (/owconcentrationof activin treat-ment) to dorsal type mesoderm(middleor high concentrationof actwintreat- et al., 1991a,b; Nakamura et al.,1992; Fukui et al., 1993), High concen-tration of activin also inducedthe beat-in theexplant(Moriya and1992) and the combinationofand retinoicaCid inducedthe(Monya et al., 1993)
Fig. 4. Diagramofderm-inducingtransduction. regulationof meso-factor(MIF)andsignalActivins bind with follistatin tomakeinactiveform.MIFs activatetheir ownreceptorstotransfertheirsignalsintothecytop/8sm8nd nucleusto expressthe earlyresponsegenes and (etinole aeid (RA)modu-latesthe MIFssignals.
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