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Sequential activation of Elk-1/Egr-1/GADD45α by arsenic

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Figure

Fig 1: Arsenic treatment induces Egr-1 expression. (A and B) BEAS-2B cells were treated with various concentrations of arsenic for 4 h, and mRNA expression was measured by real-time RT-PCR
Fig 2: Arsenic transcriptionally regulates Egr-1. (Left) The scheme of full-length, deleted and mutated Egr-1 regulatory sequences
Fig 3: ERK and JNK pathway is required for induction of Egr-1 by As3+. BEAS-2B cells were pretreated with 10 μM of SB 203580, LY 294002, U 0126, and 20 μM of SP 600125 for 1 h and then with or without arsenic for 4 h
Fig 6: Egr-1 transcriptionally regulates As-induced GADD45α expression. (A and B) Cells were treated with As3+ as indicated doses and hours
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