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Identification of high confidence RNA regulatory elements by combinatorial classification of RNA–protein binding sites

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Figure

Fig. 1 CLIP-seq data for different RBPs, CLIP technologies, and peak calling methods.defined by different peak calling methods for example RBPs.peaks are defined by Piranha (from signal height) and PARalyzer (from T to C mutation), respectively.binding pea
Fig. 2 Integrative analytical pipeline for defining high-confidence RNA sequences/motifs bound by RBP groups.PAR-CLIP and HITS-CLIP) datasets of 48 human RBPs from HEK293/HEK293T cell lines were collected
Fig. 3 NMF inferred RBP groups from multiple RBPs. a Hierarchical clustering of the Spearman correlation coefficients between every two RBPs.b Criteria for estimating rank R in NMF
Fig. 4 Enriched RNA motifs related to the RBP groups. a The histogram shows the genomic distribution of group-related binding sites for eachgroup (with at least two RBP components)
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