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PD-1 pathway inhibitors: The next generation of immunotherapy for advanced melanoma

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Figure

Table 1: Mechanism of action of anticancer agents in melanoma and association with response patterns and safety profile [4, 7, 10, 12, 13, 16–25]
Figure 1: Role of CTLA-4 and PD-1 in antitumor immune responses. Naïve T cells are primed by antigens presented by APCs in the context of MHC (signal 1), as well as co-stimulatory binding of CD28 to B7 (CD80/86) (signal 2)
Figure 2: (A) CTLA-4 checkpoint inhibition. CTLA-4 inhibition prevents early deactivation of T cells responding to tumor antigens presented by APCs
Table 2: Select immunologic adverse events reported in patients with melanoma receiving checkpoint inhibitors [12, 17, 21, 38, 40–46]
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