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β-catenin stabilization enhances SS18-SSX2 -driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition

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Academic year: 2020

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Figure

Figure 1: β-catenin stabilization enhances SS18-SSX2-driven tumorigenesis. A. Schematics represent the conditional alleles for expression of SS18-SSX2 from the Rosa26 locus, Luciferase from a CAG promoter in the 3′ untranslated region of the RNA polymerase
Figure 2: Tumors developing in mice with stabilized β-catenin are synovial sarcomas by transcriptome
Figure 3: Initiation of tumors with injected TATCre enables comparison of SS18-SSX2-induced tumors with and with genetic stabilization of β-catenin
Figure 4: Stabilization of β-catenin drives an EMT transcriptional signature and increases expression of TCF/LEF target genes

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