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Endoplasmic reticulum-Golgi intermediate compartment protein 3 knockdown suppresses lung cancer through endoplasmic reticulum stress-induced autophagy

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Figure

Figure 1: ERGIC3 expression in tumor tissues and effect of shERGIC3 downregulation. (A) Densitometric analysis of ERGIC3 protein on Western blot in human normal and adenocarcinoma lung tissues
Figure 2: Suppression of ERGIC3 induces ER stress-induced autophagy in A549 cells. (A) Western blot analyses of ERGIC3, CHOP, Calnexin, IRE1α, p62/SQSTM1 and LC3 in A549 control, shScr and shERGIC3 groups
Figure 3: Subcellular localization of ERGIC3 and relation to ER stress. (A) Confocal laser scanning microscope (CLSM) data analysis of ERGIC3 (Green) and an ER marker (Red)
Figure 4: shERGIC3 suppresses lung tumorigenesis in K-rasLA1 mice. Aerosols of GPT-SPE/shERGIC3 complexes were delivered to K-rasLA1 mice twice a week for 4 weeks (eight times)
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