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Hoxa2 downregulates Six2 in the neural crest derived mesenchyme

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Figure

Fig. 2. The expression of other Six family members is not affected byembryos using specific primers for GADPHHoxa2
Fig. 3. Middle ear skeletal phenotype of horn; m, malleus; s, styloid process; st, stapes; t,a2-Six2transgenics
Fig. 5. Identification of a promoter fragment responsive to Hoxa2.(A) The most proximal 900 bp of the Six2 promoter (–893; +37) aresufficient to drive lacZ expression in the proximal area of the firstbranchial arch, similarly to Six2 endogenous expression
Fig. 6. Hoxa2 binds the the TATA box. Sequences showing 95%promoter: the black rectangle corresponds to(A) Schematic representation of the 900Six2 promoter.Six2conservation between mouse and human are
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