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The zebrafish iguana locus encodes Dzip1, a novel zinc finger protein required for proper regulation of Hedgehog signaling

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Figure

Fig. 1. Aberrant expression of Hh target genes in regions ofmaintained in somites of the other four mutants, mount and in cross-sections
Table 1. Summary of epistasis analyses
Fig. 4. Inhibition of PKA does not activate Hh target genes.ptc1(B) and dnPKA did not induce the expression of (A-C) Injection of 250 pg of dnPKA mRNA into wild-type embryosinduced the ectopic expression of myod at 12 hpf (A), ptc1 at 30 hpfnk2.2at 30 hpf
Fig. 5. Activation of PKA does not efficiently suppress Hh targetgene expression. (A-D) In wild-type embryos, the expression ofmyod at 14 hpf (A), nk2.2 at 30 hpf (B), en1 at 30 hpf (C) and ptc1 at30 hpf (D) is repressed by 75 µM forskolin treatment
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