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Regulation of bone by the adaptive immune system in arthritis

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Figure

Figure 1. Signaling cascades during osteoclastogenesis. Receptor activator of nuclear factor-κB ligand (RANKL)-RANK binding results in the recruitment of tumor necrosis factor receptor-associated factor 6 (TRAF 6), which activates nuclear factor-κB (NF-κB)
Figure 2. Regulation of osteoclast diff erentiation by T cells in rheumatoid arthritis
Figure 3. IκBζ and ROR nuclear receptors synergistically promote Th17 development. Interleukin (IL)-6 and transforming growth factor-β (TGF-β) induce Th17 cell diff erentiation, in which the ROR nuclear receptors, RORγt and RORα, have an indispensable role

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