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Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis

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Figure

Figure 1. (a) Methyl-MAPS analysis of CDH1 and RB1 genes. Along the top of the figure, tick marks indicate locations of individual CpG sites (black), RE (red) and McrBC (blue) recognition sequences
Figure 2. Genome demethylation in mammary carcinoma tumors and cell lines. (a) Re-sistance to digestion by the methylation-dependent endonuclease complex McrBC (M) indicates demethylation, while resistance to digestion by the RE (R) cocktail of methyla-tio
Figure 3. (a) CpG density (green) and the fraction of CpGs methylated are plotted as functions of distance to the TSS and 5’ splice site of the first exon (left panel) and from the 3’ and 5’ splice of internal exons (right panel)
Figure 4. Histograms showing average methylation change between 32N and 32T for CpG-poor (left) and CpG-rich proximal promoters (right)
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