INFORMATION KIT. americordblood.com

INFORMATION KIT

americordblood.com

866.503.6005

VALUE

INNOVATION

CORD BLOOD 2.0

Preserve up to two times the stem cells of a typical collection from umbilical cord blood — exclusively available through Americord

Expertise, Plus the Highest Standards

• Americord’s Executive Medical Director, Dr. Robert Dracker, is a leading hematologist and architect of the New York State Cord Blood Banking guidelines • FDA-registered and we use an AABB-accredited lab • We use the only sterile, FDA-approved cord blood bag • Americord’s Collection Kit is backed by clinical outcomes

and rigorous validations

There When You Need Us ... With Everything You Need

• Full suite of products for you and your baby: cord blood, cord tissue, and placenta tissue banking • White glove bedside pickup service by the fastest

medical courier in the U.S. • We can be reached 24/7/365 • No yearly storage fees

Innovations that Make a Difference

• Americord’s innovative Gravity Stand™_{, combined}

with our proprietary extraction process, enables you to preserve up to two times as many stem cells as a traditional cord blood collection

• We are pioneering CordAdvantage®_{, a groundbreaking}

way to get even more stem cells from cord blood • We partner with leading institutions and research

scientists to develop innovative cord blood banking technologies

AMERICORD’S FULL SUITE OF

STEM CELL BANKING PRODUCTS

Executive Medical Director with 30 years experience pioneering cord blood banking Laboratory with nearly 20 years experience processing stem cells from cord blood

The highest QUALITY stem cell banking products and services in the industry

QUALITY YOU CAN BANK ON

AN AMERICORD PROMISE

CORD TISSUE BANKING

Preserve mesenchymal stem cells genetically matched with the baby from umbilical cord tissue

PLACENTA TISSUE

BANKING

Preserve mesenchymal stem cells genetically matched with the mother from placenta tissue using Americord’s proprietary processing method

DON’T TAKE OUR WORD FOR IT.

HEAR WHAT OUR CUSTOMERS THINK...

“ When I began researching cord blood banks, I wanted to find the one with the highest standards – even if that meant I had to pay more. What a great surprise to find out that I could get the best service and the highest quality at half the price with Americord!”

- Heather R.

“ I had a million questions about cord blood banking. The staff at Americord answered them all and even explained complicated things about stem cells in plain language. They also walked me through the different options and payment plans and helped me find the one that was right for me.”

- Sameer B.

“ We decided to save our baby’s stem cells because it seems like every day there are new treatments for diseases that used to be incurable. We chose Americord because it is constantly investing in innovations in stem cell preservation and it offers cord blood products that are not available from other companies.”

- Tim F.

“ Given the advances in genetic research and the potential for life saving or possibly advancing technology, I felt it would be an investment in our child’s health to save his cord blood. After shopping around, Americord offers the most value and was extremely customer friendly. This was important to me, being a first time mother. I am recom-mending Americord to all of my friends.”

- Joanna F.

HAVING A C-SECTION?

Americord uses the only sterile exterior cord blood collection bag that has been approved by the FDA for all births, including Cesarean sections. Unlike some less expensive cord blood bags that can be adapted for C-section births, your doctor does not have to attach or sterilize any parts. Every Collection Kit contains this bag, so even if it’s a surprise C-section, we’ve got you covered.

CORD BLOOD

DID YOU KNOW...

• Stem cells from cord blood can be used to treat various medical problems for your child, his or her siblings, and other family members

• More than 80 diseases are treat-able using cord blood stem cells • Stem cells from cord blood can

only be collected and preserved right after a baby is born

WHAT IS CORD BLOOD?

Cord blood is an easily accessible source of stem cells that is available only when your baby is born. It remains in the umbilical cord and in the placenta following birth.

Blood System Building Blocks

The type of stem cells that are recovered at birth from the umbilical cord and the placenta, called cord blood stem cells, are classified as hematopoietic stem cells (HSCs). HSCs can become any of the blood cells and cellular blood components in our bodies (such as white blood cells, red blood cells, platelets, etc.). Transplants of stem cells from cord blood are an effective therapy for certain blood borne and genetic diseases, including various types of leukemia and lymphoma.

Cord Blood 2.0™ Preserves Up To Twice As Many Stem Cells

Americord takes cord blood banking to the next level with Cord Blood 2.0™, enabling you to preserve up to twice as many stem cells compared to a typical cord blood collection.

Our two-step process starts with our innovative and patent-pending*

Gravity Stand™_{, which is exclusively available through Americord,}

to collect cord blood. Your baby’s cord blood then goes through a proprietary process at our lab to extract up to twice as many stem cells compared to a traditional cord blood collection.

Cord Blood 2.0™ _{is an important advancement for parents looking}

to preserve their baby’s stem cells, and it is only available through Americord.

More Stem Cells = More Medical Options

Until now, a significant limitation of cord blood banking has been that the number of stem cells that are preserved in a typical cord blood collection are only sufficient to treat someone who weighs up to about 65 pounds if doctors follow best practices. With Cord Blood 2.0™, up to twice as many stem cells can be preserved, making it possible to treat larger patients or expand treatment opportunities for smaller patients.

* U.S. Trademark Application No. 86337453

MORE STEM CELLS

INCREASE TRANSPLANT

SUCCESS & SURVIVAL

AMOUNT OF CD34+ STEM CELLS SURVIVAL PROBABILITY AT ONE YEAR (%) LOWEST DOSE 0 20 40 60 80 100 HIGHEST DOSE <170,000 CD34+/KG CD34+/KG>540,000

Source: Influence of CD34+ cell dose and HLA disparity on treatment-related mortality and survival, Blood. 2002; 100(5): 1611-1618.

CORD TISSUE

DID YOU KNOW...

• MSCs are genetically unique to your baby and family

• MSCs are the fastest growing area of stem cell research • MSCs from cord tissue can only

be collected right after your baby is born

WHAT IS CORD TISSUE?

Cord tissue refers to the tissue of the umbilical cord (not the blood inside of it). Until recently, cord tissue was usually discarded with the placenta after birth, but research has shown that cord tissue stem cells have the potential for treating many diseases.

The Difference is in the Tissue

Cord tissue contains mesenchymal stem cells (MSCs). Unlike the stem cells that are collected from cord blood, MSCs are multipotent, which means they have the capacity to differentiate into many different types of cells, including cartilage cells, bone cells, fat cells, and many types of connective tissue, such as cardiac muscle cells. This means that MSCs could potentially be used to treat a wider range of diseases than are currently treatable. Parents-to-be who want to expand their baby’s options for future medical treatment should consider banking stem cells from their baby’s cord tissue.

NEW OPPORTUNITIES FOR

TREATMENTS AND CURES

Scientists around the world agree that MSCs from cord tissue hold great promise. There are more than 40 clinical trials currently being conducted using MSCs from cord tissue.

CLINICAL TRIALS

FROM CORD TISSUE

40

+

Spinal cord injury Liver disease

PLACENTA TISSUE

PRESERVE STEM CELLS FOR MOM TOO

The placenta, which nourishes your baby all through your pregnancy, can also be incredibly valuable immediately after your baby is born since it contains vast quantities of mesenchymal stem cells (MSCs). Placenta tissue banking, like cord tissue banking, enables you to preserve MSCs for future medical use.

Choose to store both: Two Sources of MSCs, Two Sets of Benefits

MSCs from placenta tissue and cord tissue have unique properties, which can impact how they may be used in medical therapies for both mom and baby.

MSCs from CORD TISSUE: Baby Match

• Are genetically matched with the baby and may be useful for other family members

• Have greater proliferative capacity and shorter duplication time • Are more suitable for treatment of diseases involving the brain

and spinal cord, such as multiple sclerosis and Alzheimer’s disease

MSCs from PLACENTA TISSUE: Mom Match

• Are genetically matched with the mother and may be useful for other family members

• Have greater adhesive properties, enabling them to engraft more easily during a transplant

• Have greater secretion of important growth factors

Americord’s Win-Win Innovation

Americord’s proprietary method of processing and storing MSCs from placenta tissue has resulted in the ability to not only get more MSCs from placenta tissue, but also keeps more of them healthy in case you ever need them. We have established a 99% stem cell viability rate for MSCs from placenta tissue stored in our laboratory.

AMERICORD’S EXECUTIVE MEDICAL

DIRECTOR DR. ROBERT DRACKER

At Americord, we believe in the power of rigorous scientific research, and we are proud to have one of the pioneers of cord blood banking, Dr. Robert Dracker, as our Executive Medical Director. He is a leading hematologist, pediatric oncologist, and recognized blood and stem cell banking expert.

Additionally, Dr. Dracker was an architect of the New York cord blood banking licensing requirements, which are considered to be the gold standard of cord blood banking accreditations.

Dr. Dracker leads research and development of our stem cell banking innovations and advises on all scientific and medical matters at Americord. He is also responsible for all laboratory, collection, and transport protocols and procedures, as well as licensing, accreditation, and quality controls.

• FDA-registered, AABB-accredited, and licensed by the state’s department of health

• Stem cell processing success rates

• Financial commitment to advancing therapies and technologies related to cord blood and cord tissue banking

• Disclosure of any and all doctor affiliations that extend beyond a basic provision of service related to collecting cord blood • The right to cancel your service at any time prior to collection

without being charged a cancellation fee

• Expedited delivery of stem cells from your bedside to the laboratory by a medical courier

• Clear post-collection information about your baby’s sample, including Total Nucleated Cell Count, volume of the collection, CD34+ count, viability, and sterility testing results • An experienced laboratory that is accredited and has a long

track record

• An accredited stem cell storage facility with a strong track record, robust security protocols, and rigorous benchmarks to ensure that all collections are suitable for use in medical therapies

Cord Blood 2.0™ and Gravity Stand™ launched in 2014

Funding several third-party clinical trials, including Duke University’s Traumatic Brain Injury trial

The fastest growing cord blood bank since 2011 A commitment to pioneering INNOVATIONS that help families today and tomorrow

AN AMERICORD PROMISE

WHAT TO LOOK FOR IN A CORD BLOOD BANK

Americord has set the standard for dependable, personalized customer service. Our commitment to our customers is unmatched in the industry and our state-of-the-art services make it easy to save your baby’s stem cells with a simple three-step process.

SAVE YOUR BABY’S STEM CELLS

IN THREE SIMPLE STEPS

DECIDE NOW,

ADJUST LATER

GET THE KIT THAT

MAKES LIFE EASY

ENJOY WHITE-GLOVE

ROOM SERVICE

Since half of all babies arrive before their due dates, we recommend making a decision about cord blood banking during your second trimester, but it’s never too late in your pregnancy to enroll. You can also rest easy knowing that if you change your mind about which products you want, it’s not a prob-lem, and if you decide to cancel, you can do so without paying a cancellation fee.

You will receive the Americord Collec-tion Kit as soon as you enroll. It has everything your medical practitioner needs to complete the collection of cord blood, cord tissue, and placen-ta tissue. And, it is designed to be easy to carry, so all you have to do is remember to take it to the hospital when you go to give birth.

After you give birth and the col-lection is complete, our medical courier will pick up the Collection Kit directly from your bedside and rush it to our laboratory. Americord monitors your shipment until it is safely delivered to our laboratory, which is open and fully staffed 24 hours a day, 365 days a year. As soon as your baby’s stem cells have been fully processed, we email your baby’s stem cell Certificate of Storage to you.

1.

2.

3.

Enrollment is quick and easy at:

americordblood.com/enroll or by phone at 866.503.6005

YOUR STEM CELLS FOR YOUR PRIVATE USE

Americord is a private cord blood bank, which means that your baby’s stem cells are stored for the exclusive use of your baby and family. They are immediately available if ever needed for treatment, and you can rest easy knowing that you have an exact genetic match for your baby.

BEHIND THE SCENES EXPERTISE:

AMERICORD’S LABORATORY

Americord uses Cook General BioTechnology LLC (“CGBT”) for all processing and storage of cord blood. CGBT was founded in 1997 and is registered with the FDA as a Human Cell & Tissue Products establishment. Its facility is designed to meet and exceed the needs of its customers, and has been designed with features that include: multi-layer intrusion monitoring and video surveillance; emergency power from an independent generator and a backup generator; smoke, water, and fire detection monitoring; telephony for monitoring systems; reliable freezer temperature monitoring; stand-by freezers; facility ambient temperature control; UPS battery backup systems for sensitive equipment.

Your baby’s stem cells are processed within hours of when your collection kit is received in our laboratory, even if it happens to be a holiday. We test cord blood samples before and after processing as part of our quality control to ensure that each sample is contaminant-free on arrival and continues to be during processing in our laboratory. Our screening exceeds FDA regulations for testing and quality control.

What’s in the Box?

Americord’s Collection Kit contains all of the material your medical practitioner will need to collect your baby’s cord blood, cord tissue, and placenta tissue.

• Americord’s proprietary Gravity Stand™

• The only sterile exterior cord blood collection bag that has been approved by the FDA for all births, including Cesarean sections

• A unique identifier and label that always remain with your baby’s Collection Kit and stem cell sample

Answers When You Need Them Most

Any time you have questions, Americord is just one phone call away. Our highly trained staff is available 24/7/365 to speak to you or your medical professional at every step of the way.

ViaCord CBR Cryo-Cell StemCyte FamilyCord

Cord Blood 2.0™

Collect up to 2x the stem cells

No Annual Storage Fees No Cancellation Fees FDA/AABB Accredited Lab FDA Approved C-Section Bag Quality Guarantee $90,000 $25,000 $50,000 $75,000 $50,000 Total

Cord Blood Cost (Including 20 years

of storage) $2,999

$4,625 $4,465 $4,249 $4,675 $4,140

Total

Cord Tissue Cost (Including 20 years

of storage) $1,999

$3,820

$3,470 $3,624 $3,825 $4,095

Total

Placenta Tissue Cost (Including 20 years of storage)

$1,999

THE RESULTS ARE IN:

AMERICORD IS ON TOP

Americord’s commitment to quality, innovation, and value is clear when you stack us up against our competitors.

Competitor information is based on publicly available data from the Parent’s Guide to Cord Blood Banking website as of September 2014.

AMERICORD’S FULL SUITE OF

STEM CELL BANKING PRODUCTS

20 years of storage Medical courier

Collect in all 50 states $90K quality guarantee

No cancellation fee

FDA / AABB accredited lab

$2,999

$4,998

$6,997

INCLUDED IN EVERY PURCHASE:

Visit americordblood.com/enroll or by phone at 866.503.6005

OR OR OR

$139 FOR 24 MONTHS $219 FOR 24 MONTHS $299 FOR 24 MONTHS

OR

+

+

AND

CORD BLOOD 2.0

_{+ ONE TISSUE PRODUCT}

CORD BLOOD 2.0

_{+ TWO TISSUE PRODUCTS}

CORD BLOOD 2.0

CORD BLOOD 2.0™

CORD

TISSUE TISSUECORD PLACENTA

TISSUE PLACENTA TISSUE CORD BLOOD 2.0™ CORD BLOOD 2.0™

Leukemias

Acute Leukemia

•_{Acute Lymphoblastic Leukemia} •Acute Myelogenous Leukemia

•_{Acute Biphenotypic Leukemia} •_{Acute Undifferentiated Leukemia}

Chronic Leukemia

•Chronic Myelogenous Leukemia

•_{Chronic Lymphocytic Leukemia} •Juvenile Chronic Myelogenous

Leukemia

•Juvenile Myelomonocytic Leukemia

Myelodysplastic Syndromes (sometimes called pre-leukemia)

• _{Refractory Anemia}

•Refractory Anemia with Ringed Sideroblasts

•_{Refractory Anemia with Excess Blasts} •Refractory Anemia with Excess Blasts in

Transformation

•Chronic Myelomonocytic Leukemia

Lymphomas •_{Hodgkin’s Lymphoma}

•Non-Hodgkin’s Lymphoma (Burkitt’s Lymphoma)

Inherited Red Cell (Erythrocyte) Abnormalities

•Beta Thalassemia Major (also known as Cooley’s Anemia)

•Diamond-Blackfan Anemia

•_{Pure Red Cell Aplasia} •Sickle Cell Disease

Other Disorders of Blood Cell Proliferation

Anemias

•_{Severe Aplastic Anemia} •Congenital Dyserythropoietic

Anemia

•Fanconi Anemia

•_{Paroxysmal Nocturnal Hemoglobinuria} •Pure Red Cell Aplasia

Inherited Platelet Abnormalities

•_{Amegakaryocytosis / Congenital}

Thrombocytopenia

•_{Glanzmann Thrombasthenia}

Myeloproliferative Disorders

•Acute Myelofibrosis

•_{Agnogenic Myeloid Metaplasia}

(Myelofibrosis)

•_{Polycythemia Vera} •Essential Thrombocythemia

Inherited Immune System Disorders

•Severe Combined Immunodeficiency (SCID)

•SCID with Adenosine Deaminase Deficiency

•_{SCID which is X-linked} •SCID with absence of T & B Cells

•_{SCID with absence of T Cells,}

Normal B Cells

•_{Omenn Syndrome}

Inherited Immune System Disorders: Neutropenias

•_{Kostmann Syndrome} •Myelokathexis

Inherited Immune System Disorders–Other

•_{Ataxia-Telangiectasia} •Bare Lymphocyte Syndrome

•_{Common Variable}

Immunodeficiency

•_{DiGeorge Syndrome} •Leukocyte Adhesion Deficiency

•_{Lymphoproliferative Disorders} •Lymphoproliferative Disorder,

X-linked (also known as Epstein-Barr Virus Susceptibility)

•_{Wiskott-Aldrich Syndrome}

Phagocyte Disorders

•Chediak-Higashi Syndrome

•_{Chronic Granulomatous Disease} •Neutrophil Actin Deficiency

•_{Reticular Dysgenesis}

Cancers in the Bone Marrow •_{Multiple Myeloma}

•Plasma Cell Leukemia

•_{Waldenstrom’s Macroglobulinemia}

Solid Tumors •Neuroblastoma

•_{Retinoblastoma}

Transplants for Inherited Disorders Affecting the Immune System and Other Organs

•_{Cartilage-Hair Hypoplasia}

•Gunther’s Disease (Erythropoietic Porphyria)

•_{Hermansky-Pudlak Syndrome} •Pearson’s Syndrome

•_{Shwachman-Diamond Syndrome} •Systemic Mastocytosis

Transplants for Inherited Metabolic Disorders

•_{Mucopolysaccharidosis Storage Diseases} •Hurler Syndrome (MPS-IH)

•_{Scheie Syndrome (MPS-IS)} •Hunter Syndrome (MPS-II)

•_{Sanfilippo Syndrome (MPS-III)} •Morquio Syndrome (MPS-IV)

•_{Maroteaux-Lamy Syndrome}

(MPS-VI)

•_{Sly Syndrome, Beta-Glucuronidase}

Deficienc (MPS-VII)

•_{Mucolipidosis II (I-cell Disease)} Leukodystrophy Disorders •_{Adrenoleukodystrophy (ALD)/}

Adrenomyeloneuropathy (AMN)

•_{Krabbe Disease (Globoid Cell}

Leukodystrophy)

•_{Metachromatic Leukodystrophy} •Pelizaeus-Merzbacher Disease

Lysosomal Storage Diseases •Niemann-Pick Disease •_{Sandhoff Disease} •Wolman Disease Inherited Disorders–Other •Lesch-Nyhan Syndrome •_{Osteopetrosis}

DISEASES TREATED USING UMBILICAL

CORD BLOOD STEM CELLS SINCE 2008

Source: Parent’s Guide to Cord Blood Foundation as of March 07, 2010. Please visit their web site for the most current and comprehensive information.

The American Cancer Society’s estimates about 6,020 new cases of Acute Lymphocytic Leukemia in the United States for 2014.

6,020

2014

under 5

years old

Most cases of Acute Lymphocytic Leukemia occur in children. The risk for getting Acute Lymphocytic Leukemia is highest in children under 5 years old.

Stem cell transplant is used often as part of treatment for Acute Lymphocytic Leukemia that relapses.

Stem cells from cord blood have been used to treat over 80 different diseases, including cancers, blood disorders, and immune deficiencies. Among these are leukemia, aplastic anemia, thalassemia, Hodgkin’s disease, and non-Hodgkin’s lymphoma.

THE INDUSTRY’S HIGHEST

QUALITY GUARANTEE

Q

UA

LIT

Y GUARAN

_TE

E

$90,000

This guarantee is subject to the terms detailed in the enrollment agreement.

As a valued Americord client, the viability of your baby’s umbilical cord blood stem cells is backed by our $90,000 Quality Guarantee. If your child’s cord blood unit is used in a stem cell transplant and the cells fail to engraft, Americord will pay $90,000 towards the cost of procuring stem cells from an alternative source.

LETTER FROM

THE FOUNDER

Thank you for taking the time to read through our information kit. We hope it helps you make the best decision for your baby and family when it comes to preserving your newborn’s stem cells.

Since founding Americord Registry, our singular goal has been to provide the highest quality cord blood banking services at the best value. Toward that end, we have prioritized making investments in industry-leading products and services as well as in research and development of cutting-edge technologies that are already setting new standards in our industry.

But, as much as we are intensely focused on the science of stem cells, we never forget that behind every new enrollment there is a family awaiting the arrival of their new baby (or babies!). It is a momentous time, filled with many things to do. From our 24/7/365 hotline to our white glove bedside pickup service, we aim to make every step of the process simple and easy for you. I am proud to say that our efforts to deliver the very best to our clients have been rewarded – Americord has been the fastest growing cord blood bank in the industry since 2011. We hope to be able to serve you and your family.

Martin Smithmyer President and CEO