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The role and clinical significance of DNA damage response and repair pathways in primary brain tumors

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Academic year: 2020

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Figure

Figure 1 Targeting HR repair with poly (ADP-ribose) polymerase inhibition results in tumor-specific synthetic lethality
Figure 2 Targeting GSK3β results in neuroprotection from IR-induced neurotoxicity. Model depicting potential targeting of GSK3β-NHEJsignaling pathway to decrease neurotoxicity and increase the therapeutic index of anti-glioma treatment

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