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Nutrient-stimulated insulin secretion in mouse islets is critically dependent on intracellular pH

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Figure

Figure 1changes in intracellular pHChanges in emission fluorescence of SNARF5, in response to Changes in emission fluorescence of SNARF5, in response to changes in intracellular pH: Islets loaded
Figure 3DMAGlucose induces TDP in mouse islets in the presence of Glucose induces TDP in mouse islets in the presence of DMA: Insulin secretion in response to 16.7 mM glucose,
Figure 4i acidification was produced by 40 8; * = p < 0.001, and † = p < 0.05, compared to pared to leucine without pHEffect of experimental alteration of pHon direct insulin secretion by mitochondrial secretagoguesEffect of experimental alteration of pHi
Table 1: Islet pHi (mean ± SEM) in the presence of each secretagogue
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