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Design, Synthesis, and Docking Study of Acyl Thiourea Derivatives as Possible Histone Deacetylase Inhibitors with a Novel Zinc Binding Group

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Figure

Figure 2. Figure 2.Figure 2.  Common histone deacetylase inhibitors with zinc binding group.Common histone deacetylase inhibitors with zinc binding group
Figure 3. Coordination modes of acyl thiourea derivative with metal ions as bidentate (a) or monodentate (Figure 3
Figure 5.Figure 5. Concentration-growth inhibition curve of the tested compounds against hepatic carcinoma cells (blue), colon adenocarcinoma (orange), and healthy breast cells (gray)
Figure 7. Morphology of the cell lines after treatment with compounds 4 and 5 at the IC50
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