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Hyperglutamylation of Tubulin Can either Stabilize or Destabilize Microtubules in the Same Cell

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Figure

FIG. 2. Overproduced GFP-Ttll6Ap increases the levels of tubulin polyglutamylation on ciliary and cell-body microtubules in a time- andoverexpression strength-dependent manner
FIG. 3. Tubulin hyperglutamylation stabilizes cell body microtubules. (A to I�depolymerization of cell body microtubules in the wild-type cells but not in Ttll6Ap-overproducing cells
FIG. 5. Hyperelongation of glutamyl side chains delays cilium regeneration. (A to F) Confocal immunofluorescence images of wild-type (A andB) and GFP-Ttll6Ap (C and D)-, GFP-Ttll6Ap-M241-V929-E662G (E)-, and GFP-Ttll6Ap-M241-V929 (F)-overexpressing cells that regenerated
FIG. 6. Hyperglutamylation of ciliary microtubules results in structural defects in axonemes

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