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NK cell heparanase controls tumor invasion and immune surveillance

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Figure

Figure 1. Activated NK cells express enzymatically active heparanase. (data were pooled from 2 independent experiments)
Figure 2. NK cell–intrinsic heparanase is indispensable for efficient sur-veillance of MCA-induced fibrosarcoma and RAE-1–expressing lympho-
Figure 3. Heparanase-deficient NK cells display impaired control of lung metastases. (mice were injected with 2 × 10(B6.WT), and melanoma cells and treated with either 500 Lungs were harvested on day 14 and macrometastases counted (mean ± SEM; on days –1,
Figure 4. NK cell proliferation and function are unchanged by loss of heparanase. (NKp46-iCremined by annexin V and propidium iodide staining
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