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Original Article Bindarit alleviates inflammation and early brain injury following experimental subarachnoid hemorrhage in rats

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Academic year: 2020

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Figure

Figure 1. Effects of bindarit on SAH grade and neurological scores after SAH. Bindarit did not affect the bleeding lev-el (A) bindarit attenuated neurological deficits 24 h after SAH (B) data were expressed as mean ± SD (***P<0.001 versus sham group, &&&P<0.001 versus SAH or SAH treated with vehicle).
Figure 2. Effects of bindarit on brain edema after SAH. SAH induced increased brain water content (Fig-ure 2)
Figure 4. Effects of bindarit on cellular apoptosis after SAH. TUNEL staining showed bindarit administration reduced the cellular apoptosis 24 h after SAH (A, B) Western blot analysis showed bindarit decreased the expression of cleaved caspase-3 24 h after
Figure 6. Effects of bindarit on the activation of microglia after SAH. Immunochemistry showed the microglias in-creased in number and became activated, altering their morphology with upregulating of CD11b 24 h after SAH

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