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NQO1 dependent redox cycling of idebenone : effects on cellular redox potential and energy levels

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Figure

Figure 1. Chemical structures of the quinones tested. Idebenone, CoQmoiety but differ in the alkyl tail attached to the C6-carbon atom of their quinone ring
Table 1. Steady-state kinetic constants of NQO1 and NQO2 with different quinones.
Figure 3. Idebenone and CoQ11 hour. Bars represent meanand protection of ATP levels was maintained in rotenone-treated (20 and 60CoQidebenone
Figure 4. Rescue of ATP levels is dependent on NQO1.Correlation of ATP rescue and NQO1 mRNA expression in differentidebenone in presence of 6ATP levels in presence of rotenone and idebenone relative to thedifference between ATP levels of DMSO- and rotenone
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