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Osterix acetylation at K307 and K312 enhances its transcriptional activity and is required for osteoblast differentiation

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Figure

Figure 1: the osx protein is acetylated. A. Saos-2 cells were treated with TSA (0, 15, 30, 60 nM) or SAHA (0, 15, 30, 60 nM) for 24 h
Figure 2: osx acetylation is mediated by cbP/p300. A. HEK 293T cells were transiently co-transfected with HA-Osx-GFP and p300-myc, Flag-PCAF, Flag-CBP-HA, or Flag-GCN5 expression vectors
Figure 3: Identification of the acetylated site(s) of Osx mediated by CBP. A. HEK 293T cells were transiently co-transfected with Flag-CBP-HA and HA-Osx-GFP expression plasmids or K26R, K41R, K45R, K46R, K58R, K230R, K291R, K307R, K312R mutants
Figure 4: HdAc4 mediates osx deacetylation. Afluorescence, the localization of HDAC4 was visualized by immunostaining with an anti-Flag antibody (red)
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