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Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration

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Figure

Table 1. Vitamin B12, folate, and related metabolites inserum of B12-deficient rats
Fig. 3. Simulation, via the InSilicoMetabolism (ISM) model of one-carbonmetabolism, of the effects of decreasing methionine synthase activity onformate concentrations.
Fig. 4. Simulation, via the ISM model of one-carbon metabolism, of the effectsof decreasing CBS activity on formate concentrations.
Fig. 7. Time course of formate excretion inurine (normalized to creatinine;folate-deficient (open bars) or control diet(black bars)

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