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Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

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Figure

Figure 1 PLP-ISEdel mice show motor impairments in the opengroup, an age-related difference in thigmotaxis behavior betweenthe wild-type (WT) and PLP-ISEdel mice was foundshown in a computer-generated trace of the animalover 30 minutesfield task
Figure 2 Nesting behavior is impaired in PLP-ISEdel mice. (A)(n = 6) **and the PLP-ISEdel mice.built compared to the age-matched WT mice
Figure 3 PLP-ISEdel mice have a progressive astrogliosis throughout the brain. (A) Strong increase in glial fibrillary acidic protein (GFAP)staining is seen in the PLP-ISEdel mice
Table 1 Summary of quantitative neuropathological analysis of glial fibrillary acidic protein immunohistochemistry(GFAP IHC)
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