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Multiscale Modeling of the Early CD8 T-Cell Immune Response in Lymph Nodes: An Integrative Study

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Figure

Figure 1. Experimental CD8 T-cell counts over time in mice lymph nodes. The data werecollected following intranasal H1N1 infection in C57Bl/6 mice (adoptively transferred withF5 cells 24 h prior to the infection)
Figure 2. Simplified molecular signaling pathway of a CD8 T-cell. The molecular networkgets activated by T-cell receptor (TCR) signaling once a T-cell encounters an antigenpresenting cell (APC)
Table 1. Description of the molecular signaling pathways in Figure 2.
Figure 3.), once a naïve T-cell comes into contact with an APC ita threshold and, eventually, to an effector stage when Tbet dynamically crosses a threshold.The caspase activation level is essential for cell apoptosis.enhances apoptosis of activated and ef
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