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Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration

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Figure 1. Physicochemical structure and multifunctional properties of FHE hydrogel. (A) FTIR showing the chemical structure; (B) SEM images of FHE5 hydrogel through the catheter; (I) Images presenting the adhesive characteristic to the skin for FHE-5 hydro
Figure 2. Characterization of AMSCs and AMSCs-exo. (A) Size distribution of AMSCs-exo; (B) TEM micrograph of AMSCs-exo, scale bar: 200 nm; (C) Western blot analysis of AMSCs-exo markers of Alix, CD63, CD9 and CD81; (D) flow cytometry analysis of AMSCs mark
Figure 3. Exosomes release and HUVECs biocompatibility evaluation in vitroability of HUVECs was improved after exosomes or FHE@exo treatment (scale bar: 200 assay results of HUVECs with different treatments
Figure 4. FHE@Exo hydrogel accelerated wound closure. (A) Representative images of healing process in wounds treated with FHE, exosomes, FHE@exo and control; (B) Wound closure rates of all four groups; (C) H&E staining images of full-thickness wounds on da
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