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Opposite prognostic roles of HIF1 aand HIF2a expressions in bone metastatic clear cell renal cell cancer

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Figure

Table 1: Clinicopathological characteristics of the patients with primary RCCs included in the study
Figure 1: Expressions of HIF1α and HIF2α and their regulated genes at messenger ribonucleic acid (mRNA) level in primary non-metastatic (nmRCC) and metastatic renal cancer (mRCC) and in bone metastases (bMET)
Table 2: Correlation of HIFs and their regulated genes and transcripts at mRNA (A) and protein (B) expression levels
Figure 3: Prognostic potential for distant metastasis-free survival (DMFS) and overall survival (OS) related to expression of HIF1α (pDMFS= 0.435, HRDMFS /±95%CI/ = 0.775 ± 0.639, pOS= 0.169, HROS /±95%CI/ = 0.497 ± 0.995), HIF2α (pDMFS= 0.001, HRDMFS/±95%CI/ = 0.035 ± 2.014, pOS= 0.019, HROS/±95%CI/ = 0.085 ± 2.068) and VEGFR2 (pDMFS= 0.800, HRDMFS /±95%CI/ = 1.085 ± 0.639, pOS= 0.609, HROS /±95%CI/ = 0.780 ± 0.952) at mRNA level split at the median values.
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