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10<em>H</em>-3,6-Diazaphenothiazine induces G<sub>2</sub>/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-&kappa;B and (BIRC6-XIAP) complexes

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Academic year: 2020

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Figure

Figure 1 The chemical structure of 10H-3,6-diazaphenothiazine. ©2016 informa UK Limited, trading as Taylor & Francis Group
Figure 2 The trial compound PTZ induced concentration-dependent inhibitory effects toward a2780 ovarian cancer cells after incubated for 24 hours.Notes: The results are expressed as mean percentage of living cells over untreated control, and the error bars
Figure 3 cell cytotoxicity activity of PTZ toward representative normal cell lines.Notes: PTZ expressed lesser cytotoxicity toward (A) heK293 human embryonic kidney epithelial cells and (B) h9c2 rat embryonic heart myoblast cells by employing the same prot
Figure 4 images of aO/Pi staining of a2780 cells.Notes: (A) Untreated, (B) cisplatin-treated, (C) PTZ at 0.3 µM, (D) ic50 of PTZ at 0.62 µM, and (E) PTZ at 0.9 µM; [Left] observation under magnification 200×; [Right] observation under magnification 400× un
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