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<p>Could long-term administration of melatonin to prepubertal children affect timing of puberty? A clinician&rsquo;s perspective</p>

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Figure

Figure 1 interaction of hypothalamic factors and peripheral signals on puberty onset.through copyright clearance center, inc.Notes: republished with permission of Wolters Kluwer Health, from control of the onset of puberty, Livadas S, chrousos GP, volume 2
Table 1 examples of the effects of exogenous melatonin administration on the timing of puberty in lambs, gilts, rats, and male Siberian hamsters
Figure 2 Working model indicating how the photo-inhibitory melatonergic message in short day conditions is integrated in the hypothalamus to further regulate the gonadotropic axis in the male Syrian hamster.Notes: Photo-inhibitory melatonergic message in m

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