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DNA methylation and polyamines in embryonic development and cancer

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Academic year: 2020

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Figure

Fig. 1. DNA MTase-catalyzedmethylationthe cytosinenuclearindependentlysubstratemalsin CpG..c;ontaining sequences_appeardaughterhas strongadenosylhomocysteineproducts.ofresiduein a CpG-dinucleotideofDNA.DNAMTaserecognizescyrosinesfocated5' to guaninesand ca
Fig. 2. MaintenanceDNAapproximatelyprocesslated prior to the subsequentDNA. methylationat a replicationfork.Tissue-specific patternsof cytosinemethylationin the mammaliangenomearefaithfully inheritedtrom generationto generationby meansof a post-replicative
Fig. 3. Functionaldomainsand sequenceelementsin mouseDNAMTase.The mouseDNAMTasehasa largeN-terminalregulatorydomain(amino acids1-989) and a smallerC-terminalcatalytic domain(amino acids/003-1502).It appearsto be a fusion protein,in which13alternating Lys a
Fig. 4. A simplifiedviewMTase.of thetargetcytosineflipped-outof theDNA doublehelix andburiedin theactivesitecavityof theDNAA spectacular feature of DNA MTas8,is that it forcesIts sub-strate DNA to ffip out the cytosine base it is goingto methylate to anext
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