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Statistical Methods for Testing Genetic Pleiotropy

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Figure

Figure 1Example to illustrate why the pleiotropy LRT has an approxi-increases. Hence, the correctly specivalues ofsent misspecixit measures the sum of squared differences of theunconstrained ordinary least-squares model and the constrained model,which in t
Table 2Empirical type I error rate for random correlationstructure when b1 5 1 and all other bj 5 0 ð 6¼j 1Þ; based onmultivariate normal distribution
Table 4Empirical type I error rate for random correlationstructurewhenallbj 5 0;basedonmultivariatenormaldistribution
Table 6Empirical type I error rate when allmultivariate bj 5 0; based on t distribution with 3 d.f., with common correlationstructure
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