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Fibronectin fragment induced expression of matrix metalloproteinases is mediated by MyD88 dependent TLR 2 signaling pathway in human chondrocytes

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Academic year: 2020

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Figure

Fig. 1 Differential expression of Toll-like receptor (TLR) family members in normal and osteoarthritic (OA) cartilage and fibronectinfragment (FN-f)-regulated TLR-2 expression in human chondrocytes
Fig. 2 Small interfering Toll-like receptor 2 (siTLR-2) knockdown of endogenous TLR-2 expression suppresses 29-kDa amino-terminal fibronectinproduction in culture supernatants was determined by enzyme-linked immunosorbent assay
Fig. 3 Increased Toll-like receptor (TLR)-2 expression promotes 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f)-induced matrixand MMP-3 was analyzed using Western blot analysis
Fig. 4 Small interfering Toll-like receptor 2 (siTLR-2) knockdown of endogenous TLR-2 expression inhibits 29-kDa amino-terminal fibronectinfragment (29-kDa FN-f)-mediated catabolic pathways in human chondrocytes
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