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Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling

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Figure

Fig. 1. Experimental procedures. (A) Mesoderm migrationon conditioned substratum. (Left) Mesoderm cells migrateon the extracellular matrix (ECM) of the BCR towards theanimal pole (AP) (arrow)
Fig. 2. Directional migration and its dependence onPDGFRα signaling. (A-C) Comparison of mesodermmigration on untreated tissue culture plastic (A), FN-coated plastic (B) and conditioned substratum (C).(D-I) Migration of PDGFRα-inhibited mesoderm onnormal c
Fig. 3. Interference with PDGFA function in theBCR randomizes the migration of normal mesoderm.(A-F) Normal mesoderm on substratum conditionedwith PDGFA-compromised BCR (see explanatoryscheme above)
Fig. 4. Effects of compromised PDGFAwere stained for the presence of a FN fibrilsignaling on gastrula
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