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Regionally specified human pluripotent stem cell derived astrocytes exhibit different molecular signatures and functional properties

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Figure

Fig. 1. Differentiation and gene expression of region-specific astrocytes. (A) Schematic showing the process of subtype astrocyte differentiation.Human PSCs were induced to neuroepithelia (NE) in the presence of DMH1 and SB431542 (SB) in the first week, fo
Fig. 2. Differentially expressed genes in ESC-derived regional astrocytes. (A) Pearson correlation analysis showing the similarity of total RNA-seq data for allsamples from each region (three biological replicates per region)
Fig. 3. RNA-seq pathway analysis. (A) Analysis of the differentially utilized pathways in the DFB group; boxes show the MAPK pathway found in allanalyses
Fig. 4. Physiological properties
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