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SETDB1 prevents TET2 dependent activation of IAP retroelements in naïve embryonic stem cells

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Figure

Fig. 1 SETDB1 is pivotal for ERV silencing in naïve ESCs. a Deep amplicon sequencing from oxBS-treated DNA was used to measure 5mC levels atERVs in primed and naive ESCs; each data point represents the average value from two biological replicates at a give
Fig. 2 TET2 drives IAP expression in the absence of SETDB1.IAPs in naïve ESCs (deviation
Fig. 3 TET2 does not affect DNA methylation levels at IAPs in naïve ESCs. a 5mC levels using oxBS at IAPs upon SETDB1 knockdown in naïve ESCs;
Fig. 4 SETDB1 protects IAPs from TET2-dependent loss of H4R3me2s. a, b ChIP-qPCR data for H3K4me3 and H3K9me3 (a) or H4R3me2s (b) atIAPs upon SETDB1 loss in the presence and absence of TET2 (n = 2–3; ANOVA with Sidak’s multiple comparison test, **p < 0.01,

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