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Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides

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Figure

Figure I.1. The structure of DNA. (A) X-ray crystal structure of B-form DNA.  The phosphodiester-linked deoxyribose backbone is shown in blue, and the Watson-Crick base pairs are shown in gray (PDB YSA).(B) Chemical structures of hydrogen-bonded base pai
Figure I.2. Structures of five protein-DNA complexes: NF-κB (PBD 1VKX),6 Zif68 (PDB ZAA),7 LEF-1 (PDB 2LEF),0 Ets- (PBD STW),8 and TBP (PDB TGH).9  All protein structures are determined by X-ray crystallography with the exception of Ets-, which was
Figure I.3. Chemical structures of DNA-binding natural products.  Structures of calicheamicin oligosaccha-ride, actinomycin D, chromomycin A, and distamycin A are shown with targeted DNA sequences
Figure I.4. Distamycin bound to DNA.  X-ray crystal structures of distamycin bound to DNA in (A) 1:1 (PBD DND) and (B) 2:1 (right, PDB 378D)7 conformations are shown.
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