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NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

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Figure

Figure 1: In vitroevaluated after 2 hours treatment with 0.1% DMSO or the indicated concentrations of CNX-2006; CNX-2006 in the presence of 100 µM ATP
Figure 2: In vivo18-32) IP administration of vehicle or CNX-2006 at 25 or 50 mg/kg; of vehicle or CNX-2006 at 25 or 50 mg/kg as determined by immunoblot
Figure 4: Migration and invasion. A.E-cadherin, β-catenin and vimentin protein expression in NCI-H1975 vs H1975CR cells as detected by immunoblot
Figure 5: NF-κB-mediated resistance to CNX-2006. A. Modulation of key signaling proteins in NCI-H1975 and H1975CR cells after 2 hours treatment with 0.1% DMSO or 1 µM CNX-2006; b
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