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HIF-1α downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic Mammalian Orthoreovirus

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Figure

Figure 1: Hypoxia does not interfere with MRV translation or replication in prostate tumor cells
Figure 2: MRV infected hypoxic prostate tumor cells contain diminished HIF-1α protein levels
Figure 3: MRV induced downregulation of HIF-1α occurs via ubiquitin-dependent proteasome-mediated degradation and translational inhibition
Figure 4: PAS domain region of HIF-1α is required for its MRV-induced down-regulation
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