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Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease

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Figure

Figure 1. Enhanced gut-homing potential and depletion of circulating CD27+we observed that the overall proportion of within the CD3was selectively depleted compared with sex/age/ethnicity-matched IBS controls (*tional cantly higher levels of a correspondin
Figure 2. Intestinal Vδhealthy intestine. Shown is an example flow-cytometry analysis of colonic biopsy tissue after extensive removal of the epithelium and showing positive identification of Vcells) among the egressed leukocytes in an 18-year-old patient
Figure 3. TNFα production by mucosal Vδ2 T cells is increased in CD and impaired by blockade of
Figure 4. Activated human Vδmethyl-2-buten-4-yl 4-diphosphate, tebu-bio, Peterborough, UK) together with anti-CD2/3/28 beads to activate conventional T cells (Miltenyi Biotec) in the presence of 0-50 2 T cells are highly sensitive to AZA exposure
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