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The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

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Figure

Figure 1AEB071 inhibits T cell proliferation, cytokine production in vitro, and acute contact dermatitis in vivo
Figure 2by serum creatinine values Ex vivo analysis of peripheral blood from healthy volunteers exposed to AEB071
Figure 3Clinical improvement of psoriasis as assessed by PASI scoring. Six subjects per cohort of 25, 100, 200, and 300 mg bid AEB071 and 8 subjects in the placebo group were treated for 2 weeks and followed up for another 2 weeks in the absence of any rel
Figure 4Improvement of psoriasis during treatment with AEB071 in a represen-
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