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Two-stage estimation to adjust for treatment switching in randomised trials: a simulation study investigating the use of inverse probability weighting instead of re-censoring

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Figure

Fig. 1 Overall survival in primary efficacy population. a Two-stage method with re-censoring; b Two-stage method without re-censoring.Adapted from Latimer et al, 2016 [13]
Fig. 2 One simulated dataset from Scenario 1 with no switching: (a) Overall survival Kaplan–Meier; (b) Smoothed hazard rate
Table 1 Scenarios 20 and 28 – performance measures for estimation of control arm RMST
Table 2 Scenarios 25 and 26 – performance measures for estimation of control arm RMST
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