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Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

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Academic year: 2020

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Figure

Figure 1. In vitro characterization of CD4+toxicity assay (xCelligence) was used to evaluate the lysis of non–small cell lung L55 tumor cells when treated with CAR T cells at 1:1 E:T ratio over a 20-hour period
Figure 2. Helper effect of CD4+22 days after T cell injection. Error bars represent ± SEM (expressing 4-1BB– or CD28-based CARs
Figure 3. Third-generation CARs containing ICOS and 4-1BB intracellular domains mediate enhanced antitumor effects and increased T cell persistence
Figure 4. Levels of surface CAR expression influence antitumor effects. (A and B) T cells were transduced with indicated MOI with lentiviral vectors encoding CAR proteins
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